TY - JOUR T1 - Mapping the common and distinct neural correlates of visual, rule and motor conflict JF - bioRxiv DO - 10.1101/2020.11.19.388231 SP - 2020.11.19.388231 AU - Bryony Goulding Mew AU - Darije Custovic AU - Eyal Soreq AU - Romy Lorenz AU - Ines Violante AU - Stefano Sandrone AU - Adam Hampshire Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/11/20/2020.11.19.388231.abstract N2 - Flexible behaviour requires cognitive-control mechanisms to efficiently resolve conflict between competing information and alternative actions. Whether a global neural resource mediates all forms of conflict or this is achieved within domainspecific systems remains debated. We use a novel fMRI paradigm to orthogonally manipulate rule, response and stimulus-based conflict within a full-factorial design. Whole-brain voxelwise analyses show that activation patterns associated with these conflict types are distinct but partially overlapping within Multiple Demand Cortex (MDC), the brain regions that are most commonly active during cognitive tasks. Region of interest analysis shows that most MDC sub-regions are activated for all conflict types, but to significantly varying levels. We propose that conflict resolution is an emergent property of distributed brain networks, the functional-anatomical components of which place on a continuous, not categorical, scale from domain-specialised to domain general. MDC brain regions place towards one end of that scale but display considerable functional heterogeneity.Competing Interest StatementThe authors have declared no competing interest. ER -