RT Journal Article
SR Electronic
T1 The anti-inflammatory peptide Catestatin blocks chemotaxis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.11.23.393934
DO 10.1101/2020.11.23.393934
A1 Elke M. Muntjewerff
A1 Kristel Parv
A1 Sushil K. Mahata
A1 Mia Phillipson
A1 Gustaf Christoffersson
A1 Geert van den Bogaart
YR 2020
UL http://biorxiv.org/content/early/2020/11/24/2020.11.23.393934.abstract
AB Increased levels of the anti-inflammatory peptide catestatin (CST), a cleavage product of the pro-hormone chromogranin A, correlates with less severe outcomes in hypertension, colitis and diabetes. However, it is unknown how CST reduces the infiltration of monocytes and macrophages in inflamed tissues. Here, we report that CST blocks leukocyte migration towards inflammatory chemokines. By in vitro and in vivo migration assays, we show that although CST itself is weakly chemotactic, it blocks migration of monocytes and granulocytes to inflammatory attracting factor CC-chemokine ligand 2 (CCL2) and macrophage inflammatory protein 2 (MIP-2). Moreover, it directs CX3CR1+ macrophages away from pancreatic islets. These findings support the emerging notion that CST is a key anti-inflammatory modulator.Competing Interest StatementThe authors have declared no competing interest.