RT Journal Article SR Electronic T1 MR-based camera-less eye tracking using deep neural networks JF bioRxiv FD Cold Spring Harbor Laboratory SP 2020.11.30.401323 DO 10.1101/2020.11.30.401323 A1 Frey, Markus A1 Nau, Matthias A1 Doeller, Christian F. YR 2020 UL http://biorxiv.org/content/early/2020/12/01/2020.11.30.401323.abstract AB Viewing behavior provides a window into many central aspects of human cognition and health, and it is an important variable of interest or confound in many fMRI studies. To make eye tracking freely and widely available for MRI research, we developed DeepMReye: a convolutional neural network that decodes gaze position from the MR-signal of the eyeballs. It performs camera-less eye tracking at sub-imaging temporal resolution in held-out participants with little training data and across a broad range of scanning protocols. Critically, it works even in existing datasets and when the eyes are closed. Decoded eye movements explain network-wide brain activity also in regions not associated with oculomotor function. This work emphasizes the importance of eye tracking for the interpretation of fMRI results and provides an open-source software solution that is widely applicable in research and clinical settings.Competing Interest StatementThe authors have declared no competing interest.