RT Journal Article
SR Electronic
T1 Human retrosplenial theta and alpha modulation in active spatial navigation
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.12.01.406124
DO 10.1101/2020.12.01.406124
A1 Tien-Thong Nguyen Do
A1 Chin-Teng Lin
A1 Klaus Gramann
YR 2020
UL http://biorxiv.org/content/early/2020/12/02/2020.12.01.406124.abstract
AB Spatial navigation is a complex cognitive process based on multiple senses that are integrated and processed by a wide network of brain areas. Previous studies have revealed the retrosplenial complex (RSC) to be modulated in a task-related manner during navigation. However, these studies restricted participants’ movement to stationary setups, which might have impacted heading computations due to the absence of vestibular and proprioceptive inputs. Here, we investigated neural dynamics of RSC in an active spatial navigation task where participants actively ambulated from one location to several other points while the position of a landmark and the starting location were updated. The results revealed theta power in the RSC to be pronounced during heading changes but not during translational movements, indicating that physical rotations induce human RSC theta activity. This finding provides a potential evidence of head-direction computation in RSC in healthy humans during active spatial navigation.Competing Interest StatementThe authors have declared no competing interest.