%0 Journal Article %A Daniel R. Garza %A Marcel C. Van Verk %A Martijn A. Huynen %A Bas E. Dutilh %T Bottom-up ecology of the human microbiome: from metagenomes to metabolomes %D 2016 %R 10.1101/060673 %J bioRxiv %P 060673 %X The environmental metabolome is a dominant and essential factor shaping microbial communities. Thus, we hypothesized that metagenomic datasets could reveal the quantitative metabolic status of a given sample. Using a newly developed bottom-up ecology algorithm, we predicted high-resolution metabolomes of hundreds of metagenomic datasets from the human microbiome, revealing body-site specific metabolomes consistent with known metabolomics data, and suggesting that common cosmetics ingredients are some of the major metabolites shaping the human skin microbiome. %U https://www.biorxiv.org/content/biorxiv/early/2016/06/24/060673.full.pdf