PT  - JOURNAL ARTICLE
AU  - Daniel R. Garza
AU  - Marcel C. Van Verk
AU  - Martijn A. Huynen
AU  - Bas E. Dutilh
TI  - Bottom-up ecology of the human microbiome: from metagenomes to metabolomes
AID  - 10.1101/060673
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 060673
4099  - http://biorxiv.org/content/early/2016/06/24/060673.short
4100  - http://biorxiv.org/content/early/2016/06/24/060673.full
AB  - The environmental metabolome is a dominant and essential factor shaping microbial communities. Thus, we hypothesized that metagenomic datasets could reveal the quantitative metabolic status of a given sample. Using a newly developed bottom-up ecology algorithm, we predicted high-resolution metabolomes of hundreds of metagenomic datasets from the human microbiome, revealing body-site specific metabolomes consistent with known metabolomics data, and suggesting that common cosmetics ingredients are some of the major metabolites shaping the human skin microbiome.