PT  - JOURNAL ARTICLE
AU  - Yuusuke Nonomura
TI  - Measurement and self-operating computer of the leukocyte continuum as a fixed space–time continuum in inflammation
AID  - 10.1101/543611
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 543611
4099  - http://biorxiv.org/content/early/2019/02/08/543611.short
4100  - http://biorxiv.org/content/early/2019/02/08/543611.full
AB  - Motivation No biomarkers and systems, including leukocyte count and flow cytometry, can be used to measure tissue injury for diagnosing inflammation. A fixed space–time continuum (SτC) biomarker can address this issue. A leukocyte continuum (LC) is a biomarker forming a SτC capable of measuring injury by operators and equations for a self-operating computation.Results A self-operating computer (SOC) LC as a water treatment for leukocyte(s) was generated using leukocyte(s). String leukocyte continuum (StrLC), single-layer leukocyte (SLL) and multilayer leukocyte continuum (MLC) were demonstrated in various LCs using an equation with a primitive-operator. In the SOC, the LC is the inflammation graph of the operation result. The relative differential equation (RDE) shows how to recognize the LC not as a ‘model’ in the conventional-other-operating-computer (cOOC), but as an actual arithmetic unit with a display unit. The SOC shows the essential nature in real time.