RT Journal Article SR Electronic T1 Natural SARS-CoV-2 infections, including virus isolation, among serially tested cats and dogs in households with confirmed human COVID-19 cases in Texas, USA JF bioRxiv FD Cold Spring Harbor Laboratory SP 2020.12.08.416339 DO 10.1101/2020.12.08.416339 A1 Sarah A. Hamer A1 Alex Pauvolid-CorrĂȘa A1 Italo B. Zecca A1 Edward Davila A1 Lisa D. Auckland A1 Christopher M. Roundy A1 Wendy Tang A1 Mia Torchetti A1 Mary Lea Killian A1 Melinda Jenkins-Moore A1 Katie Mozingo A1 Yao Akpalu A1 Ria R. Ghai A1 Jessica R. Spengler A1 Casey Barton Behravesh A1 Rebecca S. B. Fischer A1 Gabriel L. Hamer YR 2020 UL http://biorxiv.org/content/early/2020/12/08/2020.12.08.416339.abstract AB The natural infections and epidemiological roles of household pets in SARS-CoV-2 transmission are not understood. We conducted a longitudinal study of dogs and cats living with at least one SARS-CoV-2 infected human in Texas and found 47.1% of 17 cats and 15.3% of 59 dogs from 25.6% of 39 households were positive for SARS-CoV-2 via RT-PCR and genome sequencing or neutralizing antibodies. Virus was isolated from one cat. The majority (82.4%) of infected pets were asymptomatic. Re-sampling of one infected cat showed persistence of viral RNA at least 32 d-post human diagnosis (25 d-post initial test). Across 15 antibody-positive animals, titers increased (33.3%), decreased (33.3%) or were stable (33.3%) over time. A One Health approach is informative for prevention and control of SARS-CoV-2 transmission.Competing Interest StatementThe authors have declared no competing interest.