RT Journal Article
SR Electronic
T1 Persistent Cellular Immunity to SARS-CoV-2 Infection
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.12.08.416636
DO 10.1101/2020.12.08.416636
A1 Breton, Gaëlle
A1 Mendoza, Pilar
A1 Hagglof, Thomas
A1 Oliveira, Thiago Y.
A1 Schaefer-Babajew, Dennis
A1 Gaebler, Christian
A1 Turroja, Martina
A1 Hurley, Arlene
A1 Caskey, Marina
A1 Nussenzweig, Michel C.
YR 2020
UL http://biorxiv.org/content/early/2020/12/09/2020.12.08.416636.abstract
AB SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4+ and CD8+ T cells, expression of activation/exhaustion markers, and cell division.Summary We show that SARS-CoV-2 infection elicits broadly reactive and highly functional memory T cell responses that persist 6 months after infection. In addition, recovered individuals show enduring immune alterations in CD4+ and CD8+ T cells compartments.Competing Interest StatementThe authors have declared no competing interest.