RT Journal Article
SR Electronic
T1 Global Age-Specific Patterns of Cyclic Gene Expression Revealed by Tunicate Transcriptome Atlas
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.12.08.417055
DO 10.1101/2020.12.08.417055
A1 Yotam Voskoboynik
A1 Aidan Glina
A1 Mark Kowarsky
A1 Chiara Anselmi
A1 Norma F Neff
A1 Katherine J Ishizuka
A1 Karla J Palmeri
A1 Benyamin Rosental
A1 Tal Gordon
A1 Stephen R Quake
A1 Irving L Weissman
A1 Rachel Ben-Shlomo
A1 Debashis Sahoo
A1 Ayelet Voskoboynik
YR 2020
UL http://biorxiv.org/content/early/2020/12/09/2020.12.08.417055.abstract
AB Expression levels of circadian clock genes, which regulate 24-hour rhythms of behavior and physiology, have been shown to change with age. However, a study holistically linking aging and circadian gene expression is missing. Using the colonial chordate Botryllus schlosseri, we combined transcriptome sequencing and stem cell-mediated aging phenomena to test how circadian gene expression changes with age. This revealed that B. schlosseri clock and clock-controlled genes oscillate organism-wide, with daily, age-specific amplitudes and frequencies. These age-related, circadian patterns persist at the tissue level, where dramatic variations in cyclic gene expression of tissue profiles link to morphological and cellular aging phenotypes. Similar cyclical expression differences were found in hundreds of pathways associated with known hallmarks of aging, as well as pathways that were not previously linked to aging. The atlas we developed points to alterations in circadian gene expression as a key regulator of aging.One Sentence Summary The Ticking Clock: Systemic changes in circadian gene expression correlates with wide-ranging phenotypes of agingCompeting Interest StatementThe authors have declared no competing interest.