PT  - JOURNAL ARTICLE
AU  - Julien Delafontaine
AU  - Alexandre Masselot
AU  - Robin Liechti
AU  - Dmitry Kuznetsov
AU  - Ioannis Xenarios
AU  - Sylvain Pradervand
TI  - Varapp: A reactive web-application for variants filtering
AID  - 10.1101/060806
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 060806
4099  - http://biorxiv.org/content/early/2016/06/27/060806.short
4100  - http://biorxiv.org/content/early/2016/06/27/060806.full
AB  - Summary: Varapp is an open-source web application to filter variants from large sets of exome data stored in a relational database. Varapp offers a reactive graphical user interface, very fast data pro-cessing, security and facility to save, reproduce and shareresults. Typically, a few seconds suffice to apply non-trivial filters to a set of half a million variants and extract a handful of potential clinically relevant targets. Varapp implements different scenarios for Mendelian diseases (dominant, recessive, de novo, X-linked, andcompound heterozygous), and allows searching for variants in genes or chro-mosomal regions of interest.Availability: The application is made of a Javascript front-end and a Python back-end. Its source code is hosted at https://github.com/varapp. A demo version isavailable at https://varapp-demo.vital-it.ch. The full documentation can be found at https://varapp-demo.vital-it.ch/docs.Contact: sylvain.pradervand{at}chuv.ch