RT Journal Article
SR Electronic
T1 Information transfer and recovery for the sense of touch
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.12.08.415729
DO 10.1101/2020.12.08.415729
A1 Chao Huang
A1 Bernhard Englitz
A1 Andrey Reznik
A1 Fleur Zeldenrust
A1 Tansu Celikel
YR 2020
UL http://biorxiv.org/content/early/2020/12/15/2020.12.08.415729.abstract
AB Transformation of postsynaptic potentials (PSPs) into action potentials (APs) is the rate-limiting step of communication in neural networks. The efficiency of this intracellular information transfer also powerfully shapes stimulus representations in sensory cortices. Using whole-cell recordings and information-theoretic measures, we show herein that somatic PSPs accurately represent stimulus location on a trial-by-trial basis in single neurons even 4 synapses away from the sensory periphery in the whisker system. This information is largely lost during AP generation but can be rapidly (<20 ms) recovered using complementary information in local populations in a cell-type-specific manner. These results show that as sensory information is transferred from one neural locus to another, the circuits reconstruct the stimulus with high fidelity so that sensory representations of single neurons faithfully represent the stimulus in the periphery, but only in their PSPs, resulting in lossless information processing for the sense of touch in the primary somatosensory cortex.Competing Interest StatementThe authors have declared no competing interest.APAction potential / spikePWPrincipal whiskerHEntropySStimulusΔTVariation in spike timingL(Cortical) layerPSPPostsynaptic potentialSWSurround whiskerI(Mutual) InformationPSTHPeristimulus time histogramΔCVariation in spike rateCSRColumnar Synchronous Response