RT Journal Article
SR Electronic
T1 Activity flow underlying abnormalities in brain activations and cognition in schizophrenia
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.12.16.423109
DO 10.1101/2020.12.16.423109
A1 Hearne, Luke J.
A1 Mill, Ravi D.
A1 Keane, Brian P.
A1 Repovš, Grega
A1 Anticevic, Alan
A1 Cole, Michael W.
YR 2020
UL http://biorxiv.org/content/early/2020/12/18/2020.12.16.423109.abstract
AB Cognitive dysfunction is a core feature of many brain disorders such as schizophrenia (SZ), and has been linked to both aberrant brain functional connectivity (FC) and aberrant cognitive brain activations. We propose that aberrant network activity flow over FC pathways leads to altered cognitive activations that produce cognitive dysfunction in SZ. We tested this hypothesis using activity flow mapping – an approach that models the movement of task-related activity between brain regions as a function of FC. Using fMRI data from SZ individuals and healthy controls during a working memory task, we found that activity flow models accurately predict aberrant cognitive activations across multiple brain networks. Within the same framework, we simulated a connectivity-based clinical intervention, predicting specific treatments that normalized brain activations and behavior in independent patients. Our results suggest that dysfunctional task-evoked activity flow is a large-scale network mechanism contributing to the emergence of cognitive dysfunction in SZ.Competing Interest StatementThe authors have declared no competing interest.