RT Journal Article
SR Electronic
T1 Recovery of neural dynamics criticality in personalized whole brain models of stroke
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.12.17.423349
DO 10.1101/2020.12.17.423349
A1 Rodrigo P. Rocha
A1 Loren Koçillari
A1 Samir Suweis
A1 Michele De Filippo De Grazia
A1 Michel Thiebaut de Schotten
A1 Marco Zorzi
A1 Maurizio Corbetta
YR 2020
UL http://biorxiv.org/content/early/2020/12/20/2020.12.17.423349.abstract
AB The critical brain hypothesis states that biological neuronal networks, because of their structural and functional architecture, work near phase transitions for optimal response to internal and external inputs. Criticality thus provides optimal function and behavioral capabilities. We test this hypothesis by examining the influence of brain injury (strokes) on the criticality of neural dynamics estimated at the level of single subjects using whole-brain models. Lesions engendered a sub-critical state that recovered over time in parallel with behavior. Notably, this improvement of criticality depended on the re-modeling of specific white matter connections. In summary, personalized whole-brain dynamical models poised at criticality track neural dynamics, alteration post-stroke, and behavior at the level of single subjects.Competing Interest StatementThe authors have declared no competing interest.