@article {He061911, author = {Zhangyi He and Mark Beaumont and Feng Fu}, title = {Effects of the Ordering of Natural Selection and Population Regulation Mechanisms on Wright-Fisher Models}, elocation-id = {061911}, year = {2016}, doi = {10.1101/061911}, publisher = {Cold Spring Harbor Laboratory}, abstract = {The Wright-Fisher model and its extensions are of central importance in population genetics, and so far, they have formed the basis of most theoretical and applied population genetic research. In the present work, we explore the effect that the ordering of natural selection and population regulation in the life cycle has on the resulting population dynamics under the Wright-Fisher model, especially for the evolution of one- and two-locus systems. With weak natural selection, the details of how to order natural selection and population regulation in the life cycle do not matter in the Wright-Fisher model and its diffusion approximation. By contrast, we show that when there is strong natural selection and the population is in linkage disequilibrium, there can be appreciable differences in the resulting population dynamics under the Wright-Fisher model, depending on whether natural selection occurs before or after population regulation in the life cycle. We argue that this effect may be of significance in natural populations subject to gene migration and local selection.F.Y. supported in part by EPSRC Grant EP/I028498/1.}, URL = {https://www.biorxiv.org/content/early/2016/07/04/061911}, eprint = {https://www.biorxiv.org/content/early/2016/07/04/061911.full.pdf}, journal = {bioRxiv} }