PT  - JOURNAL ARTICLE
AU  - Kuo‐Hua Huang
AU  - Peter Rupprecht
AU  - Michael Schebesta
AU  - Fabrizio Serluca
AU  - Kyohei Kitamura
AU  - Tewis Bouwmeester
AU  - Rainer W. Friedrich
TI  - Predictive neural processing in adult zebrafish depends on shank3b
AID  - 10.1101/546457
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 546457
4099  - http://biorxiv.org/content/early/2019/02/11/546457.short
4100  - http://biorxiv.org/content/early/2019/02/11/546457.full
AB  - Intelligent behavior requires a comparison between the predicted and the actual consequences of behavioral actions. According to the theory of predictive processing, this comparison relies on a neuronal error signal that reflects the mismatch between an internal prediction and sensory input. Inappropriate error signals may generate pathological experiences in neuropsychiatric conditions. To examine the processing of sensorimotor prediction errors across different telencephalic brain areas we optically measured neuronal activity in head-fixed, adult zebrafish in a virtual reality. Brief perturbations of visuomotor feedback triggered distinct changes in swimming behavior and different neuronal responses. Neuronal activity reflecting sensorimotor mismatch, rather than sensory input or motor output alone, was prominent throughout multiple forebrain areas. This activity preceded and predicted the transition in motor behavior. Error signals were altered in specific forebrain regions by a mutation in the autism-related gene shank3b. Predictive processing is therefore a widespread phenomenon that may contribute to disease phenotypes.