TY - JOUR T1 - Making the invisible enemy visible JF - bioRxiv DO - 10.1101/2020.10.07.307546 SP - 2020.10.07.307546 AU - Tristan Croll AU - Kay Diederichs AU - Florens Fischer AU - Cameron Fyfe AU - Yunyun Gao AU - Sam Horrell AU - Agnel Praveen Joseph AU - Luise Kandler AU - Oliver Kippes AU - Ferdinand Kirsten AU - Konstantin Müller AU - Kristoper Nolte AU - Alex Payne AU - Matt Reeves AU - Jane Richardson AU - Gianluca Santoni AU - Sabrina Stäb AU - Dale Tronrud AU - Lea von Soosten AU - Christopher Williams AU - Andrea Thorn Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/12/28/2020.10.07.307546.abstract N2 - During the COVID-19 pandemic, structural biologists rushed to solve the structures of the 28 proteins encoded by the SARS-CoV-2 genome in order to understand the viral life cycle and enable structure-based drug design. In addition to the 204 previously solved structures from SARS-CoV-1, 548 structures covering 16 of the SARS-CoV-2 viral proteins have been released in a span of only 6 months. These structural models serve as the basis for research to understand how the virus hijacks human cells, for structure-based drug design, and to aid in the development of vaccines. However, errors often occur in even the most careful structure determination - and may be even more common among these structures, which were solved quickly and under immense pressure.The Coronavirus Structural Task Force has responded to this challenge by rapidly categorizing, evaluating and reviewing all of these experimental protein structures in order to help downstream users and original authors. In addition, the Task Force provided improved models for key structures online, which have been used by Folding@Home, OpenPandemics, the EU JEDI COVID-19 challenge and others.Competing Interest StatementThe authors have declared no competing interest. ER -