PT  - JOURNAL ARTICLE
AU  - Cathy S. Chen
AU  - Evan Knep
AU  - Autumn Han
AU  - R. Becket Ebitz
AU  - Nicola M. Grissom
TI  - Sex differences in learning from exploration
AID  - 10.1101/2020.12.29.424773
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.12.29.424773
4099  - http://biorxiv.org/content/early/2020/12/29/2020.12.29.424773.short
4100  - http://biorxiv.org/content/early/2020/12/29/2020.12.29.424773.full
AB  - Sex differences in cognitive processes could set the stage for sex-modulated vulnerability to neuropsychiatric disorders. While value-based decision making processes in particular have been proposed to be influenced by sex differences, the overall correct performance across sexes often show minimal differences. Computational tools allow us to uncover latent variables in reinforcement learning that define different decision making approaches, even in animals with similar correct performance. Here, we quantify sex differences in latent variables underlying behavior in a classic value-based decision-making task: a restless 2-armed bandit. While males and females had similar accuracy, they achieved this performance via different patterns of exploration. Males made more exploratory choices overall, largely because they appeared to get stuck in exploration once they had started. Females explored less, but learned more quickly when they did so. Together, these results suggest that sex exerts stronger influences on learning and decision making during periods of self-initiated exploration than during stable choices. These findings pinpoint the neural mechanisms of exploration as potentially conferring sex-biased vulnerability to addictions, neurodevelopmental disabilities, and other neuropsychiatric disorders.Competing Interest StatementThe authors have declared no competing interest.