RT Journal Article SR Electronic T1 Genomic insights of high-risk clones of ESBL-producing Escherichia coli isolated from community infections and commercial meat in Southern Brazil JF bioRxiv FD Cold Spring Harbor Laboratory SP 2020.12.31.424884 DO 10.1101/2020.12.31.424884 A1 João Gabriel Material Soncini A1 Louise Cerdeira A1 Vanessa Lumi Koga A1 Ariane Tiemy Tizura A1 Bruna Fuga A1 Gerson Nakazato A1 Renata Katsuko Takayama Kobayashi A1 Caio Augusto Martins Aires A1 Nilton Lincopan A1 Eliana Carolina Vespero YR 2021 UL http://biorxiv.org/content/early/2021/01/02/2020.12.31.424884.abstract AB During a microbiological and genomic surveillance study to investigate the molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli from community-acquired urinary tract infections (UTI) and commercial meat samples, in a Brazilian city with a high occurrence of infections by ESBL-producing bacteria, we have identified the presence of CTX-M (-55, -27, -24, -15, -14 and -2)-producing E. coli belonging to the international clones ST354, ST131, ST117, and ST38. The ST131 was more prevalent in human samples, and worryingly the high-risk ST131-C1-M27 was identified in human infections for the first time. We also detected CTX-M-55-producing E. coli ST117 isolates from meat samples (i.e., chicken and pork) and human infections. Moreover, we have identified the important clone CTX-M-24-positive E. coli ST354 from human samples in Brazil for the first time. In brief, our results suggest a potential of commercialized meat as a reservoir of high-priority E. coli lineages in the community. In contrast, the identification of E. coli ST131-C1-M27 indicates that novel pandemic clones have emerged in Brazil, constituting a public health issue.Competing Interest StatementThe authors have declared no competing interest.