PT  - JOURNAL ARTICLE
AU  - Vivian, John
AU  - Rao, Arjun
AU  - Nothaft, Frank Austin
AU  - Ketchum, Christopher
AU  - Armstrong, Joel
AU  - Novak, Adam
AU  - Pfeil, Jacob
AU  - Narkizian, Jake
AU  - Deran, Alden D.
AU  - Musselman-Brown, Audrey
AU  - Schmidt, Hannes
AU  - Amstutz, Peter
AU  - Craft, Brian
AU  - Goldman, Mary
AU  - Rosenbloom, Kate
AU  - Cline, Melissa
AU  - O’Connor, Brian
AU  - Hanna, Megan
AU  - Birger, Chet
AU  - Kent, W. James
AU  - Patterson, David A.
AU  - Joseph, Anthony D.
AU  - Zhu, Jingchun
AU  - Zaranek, Sasha
AU  - Getz, Gad
AU  - Haussler, David
AU  - Paten, Benedict
TI  - Rapid and efficient analysis of 20,000 RNA-seq samples with Toil
AID  - 10.1101/062497
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 062497
4099  - http://biorxiv.org/content/early/2016/07/07/062497.short
4100  - http://biorxiv.org/content/early/2016/07/07/062497.full
AB  - Toil is portable, open-source workflow software that supports contemporary workflow definition languages and can be used to securely and reproducibly run scientific workflows efficiently at large-scale. To demonstrate Toil, we processed over 20,000 RNA-seq samples to create a consistent meta-analysis of five datasets free of computational batch effects that we make freely available. Nearly all the samples were analysed in under four days using a commercial cloud cluster of 32,000 preemptable cores.