RT Journal Article
SR Electronic
T1 Natural variants in SARS-CoV-2 S protein pinpoint structural and functional hotspots; implications for prophylaxis strategies
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.01.04.425340
DO 10.1101/2021.01.04.425340
A1 Suman Pokhrel
A1 Benjamin R. Kraemer
A1 Daria Mochly-Rosen
YR 2021
UL http://biorxiv.org/content/early/2021/01/06/2021.01.04.425340.abstract
AB The SARS-CoV-2 viral genome mutates incessantly as it spreads in the world and the gene for the Spike (S) protein, critical for viral transmission into humans, is no exception. Analysis of 4,517 variants isolated from humans identified regions with few mutations, thus pinpointing important functional and structural sites in the S protein. This information can guide the development of effective prophylactic agents to arrest the spread of the COVID-19 pandemic.Competing Interest StatementThe authors have declared no competing interest.