RT Journal Article
SR Electronic
T1 Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in hamsters
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.01.07.425729
DO 10.1101/2021.01.07.425729
A1 Marco Brustolin
A1 Jordi Rodon
A1 María Luisa Rodríguez de la Concepción
A1 Carlos Ávila-Nieto
A1 Guillermo Cantero
A1 Mónica Pérez
A1 Nigeer Te
A1 Marc Noguera-Julián
A1 Víctor Guallar
A1 Alfonso Valencia
A1 Núria Roca
A1 Nuria Izquierdo-Useros
A1 Julià Blanco
A1 Bonaventura Clotet
A1 Albert Bensaid
A1 Jorge Carrillo
A1 Júlia Vergara-Alert
A1 Joaquim Segalés
YR 2021
UL http://biorxiv.org/content/early/2021/01/07/2021.01.07.425729.abstract
AB Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having great impact on public health, this phenomenon raises the question if immunity generated by a single infection is sufficient to provide sterilizing/protective immunity to a subsequent SARS-CoV-2 re-exposure. The Golden Syrian hamster is a manageable animal model to explore immunological mechanisms able to counteract COVID-19, as it recapitulates pathological aspects of mild to moderately affected patients. Here, we report that SARS-CoV-2-inoculated hamsters resolve infection in the upper and lower respiratory tracts within seven days upon inoculation with the Cat01 (G614) SARS-CoV-2 isolate. Three weeks after primary challenge, and despite high titers of neutralizing antibodies, half of the animals were susceptible to reinfection by both identical (Cat01, G614) and variant (WA/1, D614) SARS-CoV-2 isolates. However, upon re-inoculation, only nasal tissues were transiently infected with much lower viral replication than those observed after the first inoculation. These data indicate that a primary SARS-CoV-2 infection is not sufficient to elicit a sterilizing immunity in hamster models but protects against lung disease.Competing Interest StatementThe authors have declared no competing interest.