RT Journal Article
SR Electronic
T1 COVID-19 Severity Is Associated with Differential Antibody Fc-mediated Innate Immune Functions
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.01.11.426209
DO 10.1101/2021.01.11.426209
A1 Opeyemi S. Adeniji
A1 Leila B. Giron
A1 Netanel F Zilberstein
A1 Maliha W. Shaikh
A1 Robert A Balk
A1 James N Moy
A1 Christopher B. Forsyth
A1 Ali Keshavarzian
A1 Alan Landay
A1 Mohamed Abdel-Mohsen
YR 2021
UL http://biorxiv.org/content/early/2021/01/11/2021.01.11.426209.abstract
AB Beyond neutralization, antibodies elicit several innate immune functions including complement deposition (ADCD), phagocytosis (ADCP), and cytotoxicity (ADCC). These functions can be both beneficial (by clearing pathogens) and/or detrimental (by inducing inflammation). We tested the possibility that qualitative differences in SARS-CoV-2 specific antibody-mediated innate immune functions contribute to Coronavirus disease 2019 (COVID-19) severity. We found that antibodies from hospitalized COVID-19 patients elicited higher ADCD but lower ADCP compared to antibodies from non-hospitalized COVID-19 patients. Consistently, higher ADCD was associated with higher systemic inflammation during COVID-19. Our study points to qualitative, differential features of anti-SARS-CoV-2 antibodies as potential contributors to COVID-19 severity.Competing Interest StatementThe authors have declared no competing interest.