TY - JOUR T1 - Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease JF - bioRxiv DO - 10.1101/2020.09.24.308122 SP - 2020.09.24.308122 AU - Abhinav Sharma AU - Diego Vidaurre AU - Jan Vesper AU - Alfons Schnitzler AU - Esther Florin Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/01/13/2020.09.24.308122.abstract N2 - Pathological oscillations including elevated beta activity in the subthalamic nucleus (STN) and between STN and cortical areas are a hallmark of neural activity in Parkinson’s disease (PD). Oscillations also play an important role in normal physiological processes and serve distinct functional roles at different points in time. We characterised the effect of dopaminergic medication on oscillatory whole-brain networks in PD in a time-resolved manner by employing a hidden Markov model on combined STN local field potentials and magnetoencephalography (MEG) recordings from 17 PD patients. Dopaminergic medication led to communication within the medial and orbitofrontal cortex in the delta/theta frequency range. This is in line with deteriorated frontal executive functioning as a side effect of dopamine treatment in Parkinson’s disease. In addition, dopamine caused the beta band activity to switch from an STN-mediated motor network to a frontoparietal-mediated one. In contrast, dopamine did not modify locally-originating STN oscillations in PD. STN–STN synchrony emerged both on and off medication. By providing electrophysiological evidence for the differential effects of dopaminergic medication on the discovered networks, our findings open further avenues for electrical and pharmacological interventions in PD.Competing Interest StatementAS has been serving as a consultant for Medtronic Inc, Boston Scientific, St. Jude Medical, Gruenenthal, and has received lecture fees from Abbvie, Boston Scientific, St. Jude Medical, Medtronic Inc, UCBList of abbreviationscommsCommunication stateDBSDeep brain stimulationEEGElectroencephalographyECGElectrocardiographyEOGElectrooculographyFOFractional occupancyGMMGaussian mixture modelHMMHidden Markov modelhyperDA Hyper-dopaminergic stateintraMEDintra-medicationinterMEDinter-medicationL-DOPALevodopaLFPLocal field potentialMEGMagnetoencephalographyNNMFNon-negative matrix factorizationPDParkinson’s diseasePFCPrefrontal cortexPCAPrincipal component analysisSTNSubthalamic nucleusTDETime-delay embedding ER -