PT  - JOURNAL ARTICLE
AU  - Wibmer, Constantinos Kurt
AU  - Ayres, Frances
AU  - Hermanus, Tandile
AU  - Madzivhandila, Mashudu
AU  - Kgagudi, Prudence
AU  - Lambson, Bronwen E.
AU  - Vermeulen, Marion
AU  - van den Berg, Karin
AU  - Rossouw, Theresa
AU  - Boswell, Michael
AU  - Ueckermann, Veronica
AU  - Meiring, Susan
AU  - von Gottberg, Anne
AU  - Cohen, Cheryl
AU  - Morris, Lynn
AU  - Bhiman, Jinal N.
AU  - Moore, Penny L.
TI  - SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
AID  - 10.1101/2021.01.18.427166
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.01.18.427166
4099  - http://biorxiv.org/content/early/2021/01/19/2021.01.18.427166.short
4100  - http://biorxiv.org/content/early/2021/01/19/2021.01.18.427166.full
AB  - SARS-CoV-2 501Y.V2, a novel lineage of the coronavirus causing COVID-19, contains multiple mutations within two immunodominant domains of the spike protein. Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore 501Y.V2 shows substantial or complete escape from neutralizing antibodies in COVID-19 convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and may foreshadow reduced efficacy of current spike-based vaccines.Competing Interest StatementThe authors have declared no competing interest.