PT  - JOURNAL ARTICLE
AU  - Constantinos Kurt Wibmer
AU  - Frances Ayres
AU  - Tandile Hermanus
AU  - Mashudu Madzivhandila
AU  - Prudence Kgagudi
AU  - Bronwen E. Lambson
AU  - Marion Vermeulen
AU  - Karin van den Berg
AU  - Theresa Rossouw
AU  - Michael Boswell
AU  - Veronica Ueckermann
AU  - Susan Meiring
AU  - Anne von Gottberg
AU  - Cheryl Cohen
AU  - Lynn Morris
AU  - Jinal N. Bhiman
AU  - Penny L. Moore
TI  - SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
AID  - 10.1101/2021.01.18.427166
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.01.18.427166
4099  - http://biorxiv.org/content/early/2021/01/19/2021.01.18.427166.short
4100  - http://biorxiv.org/content/early/2021/01/19/2021.01.18.427166.full
AB  - SARS-CoV-2 501Y.V2, a novel lineage of the coronavirus causing COVID-19, contains multiple mutations within two immunodominant domains of the spike protein. Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore 501Y.V2 shows substantial or complete escape from neutralizing antibodies in COVID-19 convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and may foreshadow reduced efficacy of current spike-based vaccines.Competing Interest StatementThe authors have declared no competing interest.