RT Journal Article
SR Electronic
T1 SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.01.18.427166
DO 10.1101/2021.01.18.427166
A1 Wibmer, Constantinos Kurt
A1 Ayres, Frances
A1 Hermanus, Tandile
A1 Madzivhandila, Mashudu
A1 Kgagudi, Prudence
A1 Lambson, Bronwen E.
A1 Vermeulen, Marion
A1 van den Berg, Karin
A1 Rossouw, Theresa
A1 Boswell, Michael
A1 Ueckermann, Veronica
A1 Meiring, Susan
A1 von Gottberg, Anne
A1 Cohen, Cheryl
A1 Morris, Lynn
A1 Bhiman, Jinal N.
A1 Moore, Penny L.
YR 2021
UL http://biorxiv.org/content/early/2021/01/19/2021.01.18.427166.abstract
AB SARS-CoV-2 501Y.V2, a novel lineage of the coronavirus causing COVID-19, contains multiple mutations within two immunodominant domains of the spike protein. Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore 501Y.V2 shows substantial or complete escape from neutralizing antibodies in COVID-19 convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and may foreshadow reduced efficacy of current spike-based vaccines.Competing Interest StatementThe authors have declared no competing interest.