TY - JOUR T1 - Conserved Architecture of Brain Transcriptome Changes between Alzheimer’s Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions JF - bioRxiv DO - 10.1101/2021.01.18.426999 SP - 2021.01.18.426999 AU - Xue Wang AU - Mariet Allen AU - Joseph S. Reddy AU - Minerva M. Carrasquillo AU - Yan W. Asmann AU - Cory Funk AU - Thuy T. Nguyen AU - Kimberly G. Malphrus AU - Steven G. Younkin AU - Dennis W. Dickson AU - Nathan D. Price AU - Todd E. Golde AU - Nilüfer Ertekin-Taner Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/01/20/2021.01.18.426999.abstract N2 - We identify a striking correlation in the directionality and magnitude of gene expression changes in brain transcriptomes between Alzheimer’s disease (AD) and Progressive Supranuclear Palsy (PSP). Further, the transcriptome architecture in AD and PSP is highly conserved between the temporal and cerebellar cortices, indicating highly similar transcriptional changes occur in pathologically affected and “unaffected” areas of the brain. These data have broad implications for interpreting transcriptomic data in neurodegenerative disorders.Competing Interest StatementThe authors have declared no competing interest. ER -