TY - JOUR T1 - Assessment of Flourishing Levels of Individuals by Using Resting State fNIRS with Different Functional Connectivity Measures JF - bioRxiv DO - 10.1101/2021.01.18.427167 SP - 2021.01.18.427167 AU - Aykut Eken Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/01/20/2021.01.18.427167.abstract N2 - Flourishing is an important criterion to assess wellbeing, however, controversies remain, particularly around assessing it with self-report measures. Due to this reason, to be able to understand the underlying neural mechanisms of well-being, researchers often utilize neuroimaging techniques. However, rather than individual answers, previous neuroimaging studies using statistical approaches provided an answer in average sense. To overcome these problems, we applied machine learning techniques to discriminate 43 highly flourishing from regular flourishing individuals by using a publicly available resting state functional near infrared spectroscopy (rs-fNIRS) dataset to get an answer in individual level. We utilized both Pearson’s correlation (CC) and Dynamic Time Warping (DTW) algorithm to estimate functional connectivity from rs-fNIRS data on temporo-parieto-occipital region as input to nine different machine learning algorithms. Our results revealed that by utilizing oxyhemoglobin concentration change with Pearson’s correlation (CC – ΔHbO) and deoxy hemoglobin concentration change with dynamic time warping (DTW – ΔHb), we could be able to classify flourishing individuals with 90 % accuracy with AUC 0.90 and 0.93 using nearest neighbor and Radial Basis Kernel Support Vector Machine. This finding suggests that temporo-parieto-occipital regional based resting state connectivity might be a potential biomarker to identify the levels of flourishing and using both connectivity measures might allow us to find different potential biomarkers.Competing Interest StatementThe authors have declared no competing interest. ER -