RT Journal Article
SR Electronic
T1 Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case-control study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 063438
DO 10.1101/063438
A1 Balazard, F
A1 Le Fur, S
A1 Valtat, S
A1 ,
A1 Valleron, AJ
A1 Bougnères, P
YR 2016
UL http://biorxiv.org/content/early/2016/07/12/063438.abstract
AB Background The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown.Purpose To unravel environmental markers associated with T1D. Methods: Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends of the patients. Parents were asked to fill a 845-item questionnaire investigating the child’s environment before diagnosis. The analysis took into account the matching between cases and controls. A second analysis used propensity score methods.Results We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnut cocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a pet by old age.Conclusions The found statistical association of new environmental markers with T1D calls for replication in other cohorts and investigation of new environmental areas.