%0 Journal Article %A Sarah Hall-Swan %A Dinler A. Antunes %A Didier Devaurs %A Mauricio M. Rigo %A Lydia E. Kavraki %A Geancarlo Zanatta %T DINC-COVID: A webserver for ensemble docking with flexible SARS-CoV-2 proteins %D 2021 %R 10.1101/2021.01.21.427315 %J bioRxiv %P 2021.01.21.427315 %X Motivation Recent efforts to computationally identify inhibitors for SARS-CoV-2 proteins have largely ignored the issue of receptor flexibility. We have implemented a computational tool for ensemble docking with the SARS-CoV-2 proteins, including the main protease (Mpro), papain-like protease (PLpro) and RNA-dependent RNA polymerase (RdRp).Results Ensembles of other SARS-CoV-2 proteins are being prepared and made available through a user-friendly docking interface. Plausible binding modes between conformations of a selected ensemble and an uploaded ligand are generated by DINC, our parallelized meta-docking tool. Binding modes are scored with three scoring functions, and account for the flexibility of both the ligand and receptor. Additional details on our methods are provided in the supplementary material.Availability dinc-covid.kavrakilab.orgSupplementary information Details on methods for ensemble generation and docking are provided as supplementary data online.Contact geancarlo.zanatta{at}ufc.br, kavraki{at}rice.eduCompeting Interest StatementThe authors have declared no competing interest. %U https://www.biorxiv.org/content/biorxiv/early/2021/01/22/2021.01.21.427315.full.pdf