PT  - JOURNAL ARTICLE
AU  - Rahul Pande
AU  - Erin Teeple
AU  - Weixiao Huang
AU  - Katherine W. Klinger
AU  - Deepak Rajpal
AU  - Dinesh Kumar
TI  - Lysosomal-Immune Axis Is Associated with COVID 19 Disease Severity: Insights from Patient Single Cell Data
AID  - 10.1101/2021.01.27.428394
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.01.27.428394
4099  - http://biorxiv.org/content/early/2021/01/27/2021.01.27.428394.short
4100  - http://biorxiv.org/content/early/2021/01/27/2021.01.27.428394.full
AB  - SARS-COV-2 has become a leading cause of illness, hospitalizations, and deaths worldwide yet heterogeneity in disease morbidity remains a conundrum. In this study, we analyzed publicly available single-cell RNA-seq data from 75076 cells sequenced from clinically staged COVID-19 patients using a network approach and identified lysosomal-immune axis as a factor significantly associated with disease severity. Our results suggest modulation of lysosomal-immune pathways may present a novel drug-targeting strategy to attenuate SARS-Cov-2 infections.Competing Interest StatementR.P., E.T., W.H., K.W.K., D.R., and D.K. are employee of Sanofi.