RT Journal Article
SR Electronic
T1 An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.01.28.428569
DO 10.1101/2021.01.28.428569
A1 Dahlén, Torsten
A1 Clements, Mark
A1 Zhao, Jingcheng
A1 Olsson, Martin L
A1 Edgren, Gustaf
YR 2021
UL http://biorxiv.org/content/early/2021/01/30/2021.01.28.428569.abstract
AB There are multiple known associations between the ABO and RhD blood groups and disease. However, no systematic population-based studies elucidating associations between a large number of disease states and blood group have been conducted. Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modelled outcomes for 1,217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million unique individuals. We discovered 49 and 1 associations between a disease and ABO and RhD blood group, respectively, after adjustment for multiple testing. We identified new associations such as kidney stones and blood group B as compared to O. We also expanded previous knowledge on other associations such as pregnancy-induced hypertension and blood group A and AB as compared to O and RhD positive as compared to negative. Our findings generate strong further support for previously known associations, but also indicate new interesting relations.