RT Journal Article
SR Electronic
T1 A hardware/software system for electrophysiology “supersessions” in marmosets
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.08.09.243279
DO 10.1101/2020.08.09.243279
A1 Muthmann, Jens-Oliver
A1 Levi, Aaron J.
A1 Carney, Hayden C.
A1 Huk, Alexander C.
YR 2021
UL http://biorxiv.org/content/early/2021/02/03/2020.08.09.243279.abstract
AB We introduce a straightforward, robust method for recording and analyzing spiking activity over timeframes longer than a single session, with primary application to the marmoset (Callithrix jacchus). Although in theory the marmoset’s smooth brain allows for broad deployment of powerful tools in primate cortex, in practice marmosets do not typically engage in long experimental sessions akin to rhesus monkeys. This potentially limits their value for detailed, quantitative neurophysiological study. Here we describe chronically-implanted arrays with a 3D arrangement of electrodes yielding stable single and multi-unit responses, and an analytic method for creating “supersessions” combining that array data across multiple experiments. We could match units across different recording sessions over several weeks, demonstrating the feasibility of pooling data over sessions. This could be a key tool for extending the viability of marmosets for dissecting neural computations in primate cortex.Competing Interest StatementThe authors have declared no competing interest.