PT  - JOURNAL ARTICLE
AU  - Valentina Poltavets
AU  - Zahra Esmaeili
AU  - Sarah T. Boyle
AU  - Hayley S. Ramshaw
AU  - Angel F. Lopez
AU  - Marina Kochetkova
AU  - Michael S. Samuel
TI  - 14-3-3ζ-depletion impairs mammary gland development in the mouse
AID  - 10.1101/2021.02.03.425513
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.02.03.425513
4099  - http://biorxiv.org/content/early/2021/02/03/2021.02.03.425513.short
4100  - http://biorxiv.org/content/early/2021/02/03/2021.02.03.425513.full
AB  - The 14-3-3 family of proteins have roles in regulating several key cellular processes. While their significant structural and functional homology had informed the idea that these proteins acted redundantly, it is now becoming clear that individual family members may have tissue and context specific functions, highlighting the need for a more nuanced understanding of these important proteins. Here, we demonstrate that mice deficient in 14-3-3ζ exhibit developmental defects of the mammary epithelium, associated with dysregulation of key transcription factors involved in the maintenance of mammary stem cell populations. We believe that this model will be prove useful for investigating the role of 14-3-3ζ in the maintenance of mammary stem cell populations and elucidating the transcriptional networks driving specification of the mammary epithelium.Competing Interest StatementThe authors have declared no competing interest.