PT  - JOURNAL ARTICLE
AU  - Christian Vanhille-Campos
AU  - Anđela Šarić
TI  - Modelling the dynamics of vesicle reshaping and scission under osmotic shocks
AID  - 10.1101/2020.11.16.384602
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2020.11.16.384602
4099  - http://biorxiv.org/content/early/2021/02/05/2020.11.16.384602.short
4100  - http://biorxiv.org/content/early/2021/02/05/2020.11.16.384602.full
AB  - We study the effects of osmotic shocks on lipid vesicles via coarse-grained molecular dynamics simulations by explicitly considering the solute in the system. We find that depending on their nature (hypo- or hypertonic) such shocks can lead to bursting events or engulfing of external material into inner compartments, among other morphology transformations. We characterize the dynamics of these processes and observe a separation of time scales between the osmotic shock absorption and the shape relaxation. Our work consequently provides an insight into the dynamics of compartmentalization in vesicular systems as a result of osmotic shocks, which can be of interest in the context of early proto-cell development and proto-cell compartmentalisation.Competing Interest StatementThe authors have declared no competing interest.