RT Journal Article
SR Electronic
T1 PARAMO pipeline: reconstructing ancestral anatomies using ontologies and stochastic mapping
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 553370
DO 10.1101/553370
A1 Sergei Tarasov
A1 István Mikó
A1 Matthew Jon Yoder
A1 Josef C. Uyeda
YR 2019
UL http://biorxiv.org/content/early/2019/02/18/553370.abstract
AB Comparative phylogenetics has been largely lacking a method for reconstructing the evolution of phenotypic entities that consist of ensembles of multiple discrete traits – entire organismal anatomies or organismal body regions. In this study, we provide a new approach named PARAMO (Phylogenetic Ancestral Reconstruction of Anatomy by Mapping Ontologies) that appropriately models anatomical dependencies and uses ontology-informed amalgamation of stochastic maps to reconstruct phenotypic evolution at different levels of anatomical hierarchy including entire phenotypes. This approach provides new opportunities for tracking phenotypic radiations and evolution of organismal anatomies.