PT  - JOURNAL ARTICLE
AU  - Markus D. Schirmer
AU  - Anne-Katrin Giese
AU  - Panagiotis Fotiadis
AU  - Mark R. Etherton
AU  - Lisa Cloonan
AU  - Anand Viswanathan
AU  - Steven M. Greenberg
AU  - Ona Wu
AU  - Natalia S. Rost
TI  - Spatial signature of white matter hyperintensities in stroke patients
AID  - 10.1101/457374
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 457374
4099  - http://biorxiv.org/content/early/2019/02/18/457374.short
4100  - http://biorxiv.org/content/early/2019/02/18/457374.full
AB  - Purpose White matter hyperintensity (WMH) is a common phenotype across a variety of neurological diseases, particularly prevalent in stroke patients; however, vascular territory dependent variation in WMH burden has not yet been identified. Here, we sought to investigate the spatial specificity of WMH burden in patients with acute ischemic stroke (AIS).Materials and Methods We created a novel age-appropriate high-resolution brain template and anatomically delineated the cerebral vascular territories. We used WMH masks derived from the clinical T2 FLAIR MRI scans and spatial normalization of the template to discriminate between WMH volume within each subject’s anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA) territories. Linear regression modeling including age, sex, common vascular risk factors, and TOAST stroke subtypes was used to assess for spatial specificity of WMH volume (WMHv) in a cohort of 882 AIS patients.Results Mean age of this cohort was 65.23±14.79 years, 61.7% were male, 63.6% were hypertensive, 35.8% never smoked. Mean WMHv was 11.58c +/-13.49 cc. There were significant differences in territory-specific, relative to global, WMH burden. In contrast to PCA territory, age (0.018±0.002, p<0.001) and small-vessel stroke subtype (0.212±0.098, p<0.001) were associated with relative increase of WMH burden within the anterior (ACA and MCA) territories, whereas male sex (−0.275±0.067, p<0.001) was associated with a relative decrease in WMHv.Conclusions Our data establish the spatial specificity of WMH distribution in relation to vascular territory and risk factor exposure in AIS patients and offer new insights into the underlying pathology.