RT Journal Article SR Electronic T1 Resident memory CD8 T cells persist for years in human small intestine JF bioRxiv FD Cold Spring Harbor Laboratory SP 553792 DO 10.1101/553792 A1 Raquel Bartolomé Casado A1 Ole J.B. Landsverk A1 Sudhir Kumar Chauhan A1 Lisa Richter A1 Dang Phung A1 Victor Greiff A1 Louise Fremgaard Risnes A1 Ying Yao A1 Ralf Stefan Neumann A1 Sheraz Yaqub A1 Ole Øyen A1 Rune Horneland A1 Einar Martin Aandahl A1 Vemund Paulsen A1 Ludvig M. Sollid A1 Shuo-Wang Qiao A1 Espen S. Bækkevold A1 Frode L. Jahnsen YR 2019 UL http://biorxiv.org/content/early/2019/02/19/553792.abstract AB In human small intestine, most CD8 T cells in the lamina propria and epithelium express a resident memory (Trm) phenotype and persist for at least one year in transplanted tissue. Intestinal CD8 Trm cells have a clonally expanded immune repertoire that is stable over time and exhibit enhanced protective capabilities.HighlightsThe vast majority of CD8 T cells in the human small intestine are Trm cellsCD8 Trm cells persist for >1 year in transplanted duodenumIntraepithelial and lamina propria CD8 Trm cells show highly similar TCR repertoireIntestinal CD8 Trm cells efficiently produce cytokines and cytotoxic mediatorsIEintraepithelialLPlamina propriaRPMIRoswell Park Memorial Institute mediumSIsmall intestineTCRT cell receptorTrmresident memory T cellTxpancreatic-duodenal transplantation (of diabetes mellitus patients)