RT Journal Article
SR Electronic
T1 The structural connectome constrains fast brain dynamics
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.11.25.393017
DO 10.1101/2020.11.25.393017
A1 P Sorrentino
A1 C Seguin
A1 R Rucco
A1 M Liparoti
A1 E Troisi Lopez
A1 S Bonavita
A1 M Quarantelli
A1 G Sorrentino
A1 V Jirsa
A1 A Zalesky
YR 2021
UL http://biorxiv.org/content/early/2021/02/20/2020.11.25.393017.abstract
AB Brain activity during rest displays complex, rapidly evolving patterns in space and time. Structural connections comprising the human connectome are hypothesized to impose constraints on the dynamics of this activity. Here, we use magnetoencephalography (MEG) to quantify the extent to which fast neural dynamics in the human brain are constrained by structural connections inferred from diffusion MRI tractography. We characterize the spatio-temporal unfolding of whole-brain activity at the millisecond scale from source-reconstructed MEG data, estimating the probability that any two brain regions will significantly deviate from baseline activity in consecutive time epochs. We find that the structural connectome profoundly shapes rapid spreading of neuronal avalanches, evidenced by a significant association between these transition probabilities and structural connectivity strengths (r=0.37, p<0.0001). This finding opens new avenues to study the relationship between brain structure and neural dynamics.Competing Interest StatementThe authors have declared no competing interest.