RT Journal Article
SR Electronic
T1 Reversible fronto-occipitotemporal signaling complements task encoding and switching under ambiguous cues
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.07.29.227736
DO 10.1101/2020.07.29.227736
A1 Kaho Tsumura
A1 Keita Kosugi
A1 Yoshiki Hattori
A1 Ryuta Aoki
A1 Masaki Takeda
A1 Junichi Chikazoe
A1 Kiyoshi Nakahara
A1 Koji Jimura
YR 2021
UL http://biorxiv.org/content/early/2021/02/20/2020.07.29.227736.abstract
AB Adaptation to changing environments involves the appropriate extraction of environmental information to achieve a behavioral goal. It remains unclear how behavioral flexibility is guided under situations where the relevant behavior is ambiguous. Using functional brain mapping of machine-learning decoders and directional functional connectivity, we show that brain-wide reversible neural signaling underpins task encoding and behavioral flexibility in ambiguously changing environments. When relevant behavior is cued ambiguously during behavioral shifting, neural coding is attenuated in distributed cortical regions, but top-down signals from the prefrontal cortex complement the coding. When behavioral shifting is cued more explicitly, modality-specialized occipitotemporal regions implement distinct neural coding about relevant behavior, and bottom-up signals from the occipitotemporal region to the prefrontal cortex supplement the behavioral shift. These results suggest that our adaptation to an ever-changing world is orchestrated by the alternation of top-down and bottom-up signaling in the fronto-occipitotemporal circuit depending on the availability of environmental information.Competing Interest StatementThe authors have declared no competing interest.