RT Journal Article
SR Electronic
T1 Memory destabilization during reconsolidation – A consequence of homeostatic plasticity?
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.02.05.429950
DO 10.1101/2021.02.05.429950
A1 F.E. Amorim
A1 R.L. Chapot
A1 T.C. Moulin
A1 J.L.C. Lee
A1 O.B. Amaral
YR 2021
UL http://biorxiv.org/content/early/2021/02/21/2021.02.05.429950.abstract
AB Remembering is not a static process: when retrieved, a memory can be destabilized and become prone to modifications. This phenomenon has been demonstrated in a number of brain regions, but the neuronal mechanisms that rule memory destabilization and its boundary conditions remain elusive. Using two distinct computational models that combine Hebbian plasticity and synaptic downscaling, we show that homeostatic plasticity can function as a destabilization mechanism, accounting for behavioral results of protein synthesis inhibition upon reactivation with different reexposure times. Furthermore, by performing systematic reviews, we identify a series of overlapping molecular mechanisms between memory destabilization and synaptic downscaling, although direct experimental links between both phenomena remain scarce. In light of these results, we propose a theoretical framework where memory destabilization can emerge as an epiphenomenon of homeostatic adaptations prompted by memory retrieval.Competing Interest StatementThe authors have declared no competing interest.