PT  - JOURNAL ARTICLE
AU  - Ella V. Rodwell
AU  - Nicolas Wenner
AU  - Caisey V. Pulford
AU  - Yueyi Cai
AU  - Arthur Bowers-Barnard
AU  - Alison Beckett
AU  - Jonathan Rigby
AU  - David M. Picton
AU  - Tim R. Blower
AU  - Nicholas A. Feasey
AU  - Jay C. D. Hinton
AU  - Blanca M. Perez-Sepulveda
TI  - Isolation and characterisation of bacteriophages with activity against invasive non-typhoidal <em>Salmonella</em> causing bloodstream infection in Malawi
AID  - 10.1101/2021.02.18.431836
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.02.18.431836
4099  - http://biorxiv.org/content/early/2021/02/22/2021.02.18.431836.short
4100  - http://biorxiv.org/content/early/2021/02/22/2021.02.18.431836.full
AB  - In recent years, novel lineages of invasive non-typhoidal Salmonella (iNTS) serovars Typhimurium and Enteritidis have been identified in patients with bloodstream infection in sub-Saharan Africa. Here, we isolated and characterised 32 phages capable of infecting S. Typhimurium and S. Enteritidis, from water sources in Malawi and the UK. The phages were classified in three major phylogenetic clusters that were geographically distributed. In terms of host range, Cluster 1 phages were able to infect all bacterial hosts tested, whereas Clusters 2 and 3 had a more restricted profile. Cluster 3 contained two sub-clusters, and 3.b contained the most novel isolates. This study represents the first exploration of the potential for phages to target the lineages of Salmonella that are responsible for bloodstream infections in sub-Saharan Africa.Competing Interest StatementThe authors have declared no competing interest.