RT Journal Article
SR Electronic
T1 Innate Behavior Sequence Progression by Peptide-Mediated Interorgan Crosstalk
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.10.10.334540
DO 10.1101/2020.10.10.334540
A1 Fabiana Heredia
A1 Yanel Volonté
A1 Joana Pereirinha
A1 Magdalena Fernandez-Acosta
A1 Andreia P. Casimiro
A1 Cláudia G. Belém
A1 Filipe Viegas
A1 Kohtaro Tanaka
A1 Juliane Menezes
A1 Maite Arana
A1 Gisele A. Cardoso
A1 André Macedo
A1 Malwina Kotowicz
A1 Facundo H. Prado Spalm
A1 Marcos J. Dibo
A1 Raquel D. Monfardini
A1 Tatiana T. Torres
A1 César S. Mendes
A1 Andres Garelli
A1 Alisson M. Gontijo
YR 2021
UL http://biorxiv.org/content/early/2021/02/24/2020.10.10.334540.abstract
AB Innate behaviors consist of a succession of genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood. Here, we provide insight into these mechanisms by studying pupariation, a multi-step innate behavior of fly larvae that is critical for survival during metamorphosis. We find that the steroid-hormone ecdysone triggers parallel pupariation neuromotor and morphogenetic subprograms, which include the induction of the relaxin-peptide hormone, Dilp8, in the epidermis. Dilp8 acts on six Lgr3-positive thoracic interneurons to couple both subprograms in time and to instruct neuromotor subprogram switching during behavior. Our work reveals that interorgan feedback gates progression between subunits of an innate behavior and points to an ancestral neuromodulatory function of relaxin signaling.Competing Interest StatementThe authors have declared no competing interest.