PT - JOURNAL ARTICLE AU - William Andres Lopez-Arboleda AU - Stephan Reinert AU - Magnus Nordborg AU - Arthur Korte TI - Global genetic heterogeneity in adaptive traits AID - 10.1101/2021.02.26.433043 DP - 2021 Jan 01 TA - bioRxiv PG - 2021.02.26.433043 4099 - http://biorxiv.org/content/early/2021/02/26/2021.02.26.433043.short 4100 - http://biorxiv.org/content/early/2021/02/26/2021.02.26.433043.full AB - Understanding the genetic architecture of complex traits is a major objective in biology. The standard approach for doing so is genome-wide association studies (GWAS), which aim to identify genetic polymorphisms responsible for variation in traits of interest. In human genetics, consistency across studies is commonly used as an indicator of reliability. However, if traits are involved in adaptation to the local environment, we do not necessarily expect reproducibility. On the contrary, results may depend on where you sample, and sampling across a wide range of environments may decrease the power of GWAS because of increased genetic heterogeneity. In this study, we examine how sampling affects GWAS for a variety of phenotypes in the model plant species Arabididopsis thaliana. We show that traits like flowering time are indeed influenced by distinct genetic effects in local populations. Furthermore, using gene expression as a molecular phenotype, we show that some genes are globally affected by shared variants, while others are affected by variants specific to subpopulations. Remarkably, the former are essentially all cis-regulated, whereas the latter are predominately affected by trans-acting variants. Our result illustrate that conclusions about genetic architecture can be incredibly sensitive to sampling and population structure.Competing Interest StatementThe authors have declared no competing interest.