PT  - JOURNAL ARTICLE
AU  - Constantinos Kurt Wibmer
AU  - Frances Ayres
AU  - Tandile Hermanus
AU  - Mashudu Madzivhandila
AU  - Prudence Kgagudi
AU  - Brent Oosthuysen
AU  - Bronwen E. Lambson
AU  - Tulio de Oliveira
AU  - Marion Vermeulen
AU  - Karin van der Berg
AU  - Theresa Rossouw
AU  - Michael Boswell
AU  - Veronica Ueckermann
AU  - Susan Meiring
AU  - Anne von Gottberg
AU  - Cheryl Cohen
AU  - Lynn Morris
AU  - Jinal N. Bhiman
AU  - Penny L. Moore
TI  - SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
AID  - 10.1101/2021.01.18.427166
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.01.18.427166
4099  - http://biorxiv.org/content/early/2021/03/01/2021.01.18.427166.short
4100  - http://biorxiv.org/content/early/2021/03/01/2021.01.18.427166.full
AB  - SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.Competing Interest StatementThe authors have declared no competing interest.