RT Journal Article
SR Electronic
T1 The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.03.01.433430
DO 10.1101/2021.03.01.433430
A1 Peter S. B. Finnie
A1 Robert W. Komorowski
A1 Mark F. Bear
YR 2021
UL http://biorxiv.org/content/early/2021/03/02/2021.03.01.433430.abstract
AB The hippocampus and neocortex are theorized to be crucial partners in the formation of long-term memories. Here, we assess hippocampal involvement in two related forms of experience-dependent plasticity in the primary visual cortex (V1) of mice. Like control animals, those with hippocampal lesions exhibit potentiation of visually evoked potentials following passive daily exposure to a phase reversing oriented grating stimulus, which is accompanied by long-term habituation of a reflexive behavioral response. Thus, low-level recognition memory is formed independently of the hippocampus. However, response potentiation resulting from daily exposure to a fixed sequence of four oriented gratings is severely impaired in mice with hippocampal damage. A feature of sequence plasticity in V1 of controls, but absent in lesioned mice, is generation of predictive responses to an anticipated stimulus element when it is withheld or delayed. Thus, hippocampus is involved in encoding temporally structured experience, even in primary sensory cortex.Competing Interest StatementThe authors have declared no competing interest.