PT  - JOURNAL ARTICLE
AU  - Pengfei Wang
AU  - Maple Wang
AU  - Jian Yu
AU  - Gabriele Cerutti
AU  - Manoj S. Nair
AU  - Yaoxing Huang
AU  - Peter D. Kwong
AU  - Lawrence Shapiro
AU  - David D. Ho
TI  - Increased Resistance of SARS-CoV-2 Variant P.1 to Antibody Neutralization
AID  - 10.1101/2021.03.01.433466
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.03.01.433466
4099  - http://biorxiv.org/content/early/2021/03/02/2021.03.01.433466.short
4100  - http://biorxiv.org/content/early/2021/03/02/2021.03.01.433466.full
AB  - The relative resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to antibody neutralization has been described recently. We now report that another emergent variant from Brazil, P.1, is not only refractory to multiple neutralizing monoclonal antibodies, but also more resistant to neutralization by convalescent plasma (6.5 fold) and vaccinee sera (2.2-2.8 fold). The P.1 variant threatens current antibody therapies but less so the protective efficacy of our vaccines.Competing Interest StatementP.W., J.Y., M.N., Y.H., and D.D.H. are inventors on a provisional patent application on mAbs to SARS-CoV-2.