RT Journal Article
SR Electronic
T1 Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.03.05.434086
DO 10.1101/2021.03.05.434086
A1 Shenghong He
A1 Alceste Deli
A1 Petra Fischer
A1 Christoph Wiest
A1 Yongzhi Huang
A1 Sean Martin
A1 Saed Khawaldeh
A1 Tipu Z. Aziz
A1 Alexander L Green
A1 Peter Brown
A1 Huiling Tan
YR 2021
UL http://biorxiv.org/content/early/2021/03/07/2021.03.05.434086.abstract
AB Backgroud The pedunculopontine nucleus (PPN) is a reticular collection of neurons at the junction of the midbrain and pons, playing an important role in modulating posture and locomotion. Deep brain stimulation of the PPN has been proposed as an emerging treatment for patients with Parkinson’s disease (PD) or multiple system atrophy (MSA) suffering gait-related atypical parkinsonian syndromes.Objective In this study, we investigated PPN activities during gait to better understand its functional role in locomotion. Specifically, we investigated whether PPN activity is rhythmically modulated during locomotion.Methods PPN local field potential (LFP) activities were recorded from PD or MSA patients suffering from gait difficulties during stepping in place or free walking. Simultaneous measurements from force plates or accelerometers were used to determine the phase within each gait cycle at each time point.Results Our results showed that activities in the alpha and beta frequency bands in the PPN LFPs were rhythmically modulated by the gait phase within gait cycles, with a higher modulation index when the stepping rhythm was more regular. Meanwhile, the PPN-cortical coherence was most prominent in the alpha band. Both gait-phase related modulation in the alpha/beta power and the PPN-cortical coherence in the alpha frequency band were spatially specific to the PPN and did not extend to surrounding regions.Conclusions These results raise the possibility that alternating PPN stimulation in tandem with the gait rhythm may be more beneficial for gait control than continuous stimulation, although this remains to be established in future studies.Competing Interest StatementThe authors have declared no competing interest.