@article {Clopath066589, author = {Claudia Clopath and Tim P. Vogels and Robert C. Froemke and Henning Sprekeler}, title = {Receptive field formation by interacting excitatory and inhibitory synaptic plasticity}, elocation-id = {066589}, year = {2016}, doi = {10.1101/066589}, publisher = {Cold Spring Harbor Laboratory}, abstract = {The stimulus selectivity of synaptic currents in cortical neurons often shows a co-tuning of excitation and inhibition, but the mechanisms that underlie the emergence and plasticity of this co-tuning are not fully understood. Using a computational model, we show that an interaction of excitatory and inhibitory synaptic plasticity reproduces both the developmental and {\textendash} when combined with a disinhibitory gate {\textendash} the adult plasticity of excitatory and inhibitory receptive fields in auditory cortex. The co-tuning arises from inhibitory plasticity that balances excitation and inhibition, while excitatory stimulus selectivity can result from two different mechanisms. Inhibitory inputs with a broad stimulus tuning introduce a sliding threshold as in Bienenstock-Cooper-Munro rules, introducing an excitatory stimulus selectivity at the cost of a broader inhibitory receptive field. Alternatively, input asymmetries can be amplified by synaptic competition. The latter leaves any receptive field plasticity transient, a prediction we verify in recordings in auditory cortex.}, URL = {https://www.biorxiv.org/content/early/2016/07/29/066589}, eprint = {https://www.biorxiv.org/content/early/2016/07/29/066589.full.pdf}, journal = {bioRxiv} }