PT  - JOURNAL ARTICLE
AU  - Tsoi, Sau Yee
AU  - Öncül, Merve
AU  - Svahn, Ella
AU  - Robertson, Mark
AU  - Bogdanowicz, Zuzanna
AU  - McClure, Christina
AU  - Sürmeli, Gülşen
TI  - Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus
AID  - 10.1101/2021.03.10.434566
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.03.10.434566
4099  - http://biorxiv.org/content/early/2021/03/11/2021.03.10.434566.short
4100  - http://biorxiv.org/content/early/2021/03/11/2021.03.10.434566.full
AB  - Standard models for memory storage assume that signals reach the hippocampus from superficial layers of the entorhinal cortex (EC) and are returned to the telencephalon by projections from deep layers of the EC. Here we show that telencephalon-projecting cells in Layer 5a of the medial EC send a copy of their outputs back to the CA1 region of the hippocampus. Our results suggest that rather than serving as a relay, deep EC may coordinate hippocampal-neocortical interactions in memory consolidation.Competing Interest StatementThe authors have declared no competing interest.